Hyperalgesia, Thermal
|
0.400 |
PosttranslationalModification
|
phenotype |
BEFREE |
Together, these results demonstrate that Cdk5-mediated phosphorylation of TRPV1 at Thr-406 increases the surface level and the function of TRPV1, while the TAT-T406 peptide can effectively attenuate thermal hyperalgesia.
|
26376215 |
2015 |
Hyperalgesia, Thermal
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
To test this hypothesis, CCR1 was cotransfected into human embryonic kidney (HEK)293 cells together with transient receptor potential vanilloid 1 (TRPV1), a cation channel required for certain types of thermal hyperalgesia.
|
15764707 |
2005 |
Hyperalgesia, Thermal
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Thus, the direct anchoring of both PKA and AC to TRPV1 by AKAP79/150 facilitates the response to inflammatory mediators and may be critical in the pathogenesis of thermal hyperalgesia.
|
23264624 |
2013 |
Hyperalgesia, Thermal
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
The transient receptor potential vanilloid type 1 (TRPV1) receptor is a polymodal molecular integrator in the pain pathway expressed in Aδ- and C-fibre nociceptors and is responsible for the thermal hyperalgesia associated with inflammatory pain.
|
28094445 |
2017 |
Hyperalgesia, Thermal
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
The present results suggested that TNF-α could sensitize TRPV1 by promoting its expression, thus leading to mechanical allodynia and thermal hyperalgesia in vincristine-treated rats.
|
29552137 |
2018 |
Hyperalgesia, Thermal
|
0.400 |
Biomarker
|
phenotype |
CTD_human |
The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain.
|
23006841 |
2012 |
Hyperalgesia, Thermal
|
0.400 |
Biomarker
|
phenotype |
CTD_human |
Peripheral group II metabotropic glutamate receptors (mGluR2/3) regulate prostaglandin E2-mediated sensitization of capsaicin responses and thermal nociception.
|
12151517 |
2002 |
Hyperalgesia, Thermal
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Methods We investigated the functional roles of TRPM8 and TRPV1 in a meningeal inflammation-based migraine model by measuring the effects of facial TRPM8 activation on thermal allodynia and assessing receptor coexpression changes in TG neurons.
|
28554243 |
2018 |
Hyperalgesia, Thermal
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Intrathecal delivery of a cell-penetrating fusion peptide corresponding to the Cdk5 phosphorylation site in AP2μ2, which competed with AP2μ2 for phosphorylation by Cdk5, increased the abundance of TRPV1 on the surface of dorsal root ganglion neurons and reduced complete Freund's adjuvant (CFA)-induced inflammatory thermal hyperalgesia in rats.
|
31186372 |
2019 |
Hyperalgesia, Thermal
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, intraplantar or intrathecal administration of A-784168 blocked CFA-induced thermal hyperalgesia, suggesting that both peripheral and CNS TRPV1 receptors may play a role in inflammatory thermal hyperalgesia.
|
16971522 |
2006 |
Hyperalgesia, Thermal
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Consistent with this model, TRPV1 knock-out mice are devoid of post-inflammatory thermal hyperalgesia.
|
18209521 |
2008 |
Hyperalgesia, Thermal
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Coadministration of the cyclooxygenase inhibitor, ibuprofen, with the TRPV1 antagonist decreased inflammatory thermal hyperalgesia in transgenic but not wild-type animals.
|
19091963 |
2008 |
Hyperalgesia, Thermal
|
0.400 |
Biomarker
|
phenotype |
CTD_human |
Cannabinoids desensitize capsaicin and mustard oil responses in sensory neurons via TRPA1 activation.
|
18234885 |
2008 |
Hyperalgesia, Thermal
|
0.400 |
Biomarker
|
phenotype |
CTD_human |
Because animals treated with opiates show thermal hyperalgesia, we examined the possible role of TRPV1 receptors in the development of morphine-induced hyperalgesia using TRPV1 wild-type (WT) and knock-out (KO) mice and with administration of a TRPV1 antagonist in mice and rats.
|
18774343 |
2009 |
Hyperalgesia, Thermal
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Although it is known that sensitization of the heat transducer TRPV1 largely subserves thermal hyperalgesia, the cellular mechanisms underlying mechanical hyperalgesia have been elusive.
|
22921401 |
2012 |